Dr. Tranah is a Professor at the California Pacific Medical Center (CPMC) Research Institute and an Adjunct Professor in the Department of Epidemiology and Biostatistics at the University of California, San Francisco. Dr. Tranah’s current research program is focused on identifying inherited and acquired genetic factors that impact aging and disease with the goal of revolutionizing risk assessment and identifying widely applicable and inexpensive genomic tests that identify persons who would benefit from specific pharmacologic and behavioral treatments to prevent disability and disease.
Dr. Brooks designed and led a multi-site study for the clinical validation of an end-to-end workflow for the collection, storage, transport and preparation of human whole blood samples for RNA-Seq. The study integrated products from PreAnalytiX GmbH and the Ovation® Human Blood RNA-Seq System in a collaborative effort with RUCDR Infinite Biologics at Rutgers University to measure the system’s efficacy for transcriptome profiling with clinical samples. At the conclusion of the study it was determined that the integrated workflow ensures reproducible, accurate and sensitive results in RNA-Seq of whole blood, enabling gene expression from total RNA thereby allowing researchers to study both protein coding and regulatory transcripts from human whole blood.
Dr. Moreno-Romero's studies focus on the identification of epigenetic modifications that occur during early stages of endosperm development. DNA methylation libraries were prepared using Ovation® Ultralow Methyl-Seq Library Systems and ChIP libraries were prepared with Ovation® Ultralow Library Systems V2 using very small amounts of starting material.
Dr. Weber's research focuses on identifying the transcriptional regulators which are responsible for defining the dermal hair follicle stem cell with the goal of developing a renewable source of hair follicle stem cells for transplantation or full follicle development in vitro. The Ovation® RNA-Seq System V2 was used to prepare cDNA for sequencing libraries from very low inputs of starting material.